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It is generally accepted that the topical application of comfrey could not result in poisoning because:
Indeed, there have been no reports of poisoning from topically applied comfrey.
The extent that PAs are absorbed by the skin was explored in one limited study (two rats per group) using comfrey PAs and measuring urine excretion. Absorption by the skin results in about 20 times less metabolites in the urine than when administered orally. In addition, dermally administered PA N-Oxides of Symphytum were not converted to the parent base, while oral administration resulted in detectable amounts of the parent base in the urine.
© 2004 Dorena Rode       Acknowledgment